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CleanLine Connector

Single Use bioprocessing is on the rise as a standard for manufacturing due to the convenience, efficiency and cost savings over traditional stainless steel approaches. In many cases, a limiting factor is the time it takes to move fluid from one area of the process to another. Whether in a single use system or a hybrid stainless steel to single use application where larger connection ports are more common, rapid fluid transfer through larger hose can provide a tremendous time savings for these critical processes. Refine Technology’s CleanLine™ 1.5″ Connector and custom hose assemblies provide simpler sterile set-up and operational efficiency with higher flow rates than traditionally smaller single use connections.

The CleanLine™ Connector provides the benefits of aseptic single use capability while maintaining the reliability typically associated with traditional stainless steel technology.

  • Strong, robust 1½ ” connection for high pressure and flow rates
  • Single use supports continuous bioprocessing
  • Dual seals minimize contamination risk from the inside and outside
  • Genderless connecting: less inventory, less complexity, more flexibility
  • Connection secured with polysulfone Twist Lock Rivets
  • Cleaned, assembled and packaged in an ISO 7 Clean Room
  • Gamma and autoclave stable
  • More cost effective; less down time
  • Hose and custom assemblies available

Applications Include:

  • Upstream to downstream transfer
  • Media buffer preparation and transfer
  • Bioreactor harvest
  • Sterile waste removal from process stream
  • WFI or sterile water transfers
  • Sterile bulk formulation downloads

Anywhere in your process that could benefit from rapid, high volume sterile fluid transfers.

  • CleanLine™ Connector body material meets ISO 10993, 21 CFR 177.1655
  • Components are cleaned, assembled, and packaged in an ISO 7 clean room
  • Compatible with autoclave and gamma sterilization
  • Each lot’s materials of construction have 100% traceability
  • Gamma stable up to 50 kGy
  • Autoclave stable 124°C for 60 minutes
  • Form, fit, and function are maintained following steam and vacuum autoclave cycles
  • Vacuum hold up to 26” Hg
  • Pressure hold up to 80 psi
  • Sterility can be maintained after connection in an uncontrolled environment
  • Water flow rate of 290 liters per minute at pressure drop of 0.69 psi
  1. Press connector halves together until one hears an audible click
  2. Mate the handles and pull to remove the sanitary shields
  3. Fasten with polysulfone rivets

Operating temperature: 4°C to 50°C

Operating pressure: 26”Hg up to 5.5 bar/80 psig

Product Product Number
CleanLine™ 1.5″ Single Use Connector CLC-1.5
CleanLine™ Single Use Tri-Clamp Connector CLC-1.5-TC
Accessories for use with CleanLine 1.5″ Single Use Connector
Hose Barb to T.C. Adapter CLCOP:QP-BR
1.5″ x 6″ Fabric Reinforced Silicone Hose ST:PT-FR-1.5×6
1.5″ x 12″ Fabric Reinforced Silicone Hose ST:PT-FR-1.5×12
1.5″ x 24″ Fabric Reinforced Silicone Hose ST:PT-FR-1.5×24
1.5″ x 48″ Fabric Reinforced Silicone Hose ST:PT-FR-1.5×48
1.5″ x 6″ Stainless Steel Reinforced Silicone Hose ST:PT-SS-1.5×6
1.5″ x 12″ Stainless Steel Reinforced Silicone Hose ST:PT-SS-1.5×12
1.5″ x 24″ Stainless Steel Reinforced Silicone Hose ST:PT-SS-1.5×24
1.5″ x 48″ Stainless Steel Reinforced Silicone Hose ST:PT-SS-1.5×48

Gamma sterilized connectors and hose, custom lengths of hose, and connector and hose assemblies available upon request.

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