Posts Taged single-use

Refine Technology in Puerto Rico

March 16, 2018 – Pine Brook, NJ

Refine Technology is very pleased to present LA Industrial Supply as its new distribution partner in Puerto Rico. LA Industrial Supply is a leading provider of high quality hygienic seals, sanitary gaskets, hose assemblies, valve, pump and filler machinery components in a wide range of high purity elastomer materials.

CleanLine Connector

CleanLine 1.5″ Single Use Connector

LA Industrial Supply’s contacts and expertise in the field of biopharmaceutical manufacturing in Puerto Rico make them an excellent partner to promote Refine Technology’s CleanLine™ 1.5″ Single Use Connector in an area known for biopharmaceutical manufacturing. We are looking forward to expanding awareness and use of the CleanLine Connector to improve sterile flouid flow rates in Puerto Rico.

For more information on LA Industrial Supply and their product offerings, please visit their website at: LA Industrial Supply

For more information on Refine Technology and the CleanLine™ 1.5″ Single Use Connector, please visit us at: Refine Technology


Chris Bartlett

Business Development Director

Refine Technology

+1-973-962-0002 ext 302


New Distribution Partners for Refine Technology in Europe

January 22, 2018

Refine Technology is pleased to announce new partnerships in Europe for the promotion and sale of the CleanLine™ 1.5” Single Use Connector. The company has appointed several of the Indutrade group of companies as distribution partners. Indutrade is an international industrial group that sells high-tech products and solutions helping customers to improve their own products as well as streamline their own production processes. The continued expansion of sales channels in Europe represents a strong indication of the adoption potential for Refine Technology’s unique new connector in various single use bioprocessing applications.

Refine Technology has partnered with the following companies and regions in Europe:

CleanLine Connector

ESI – UltraPure in Ireland & the UK
ESI – Benelux in The Netherlands, Belgium & Luxembourg
Colly – Flowtech/UltraPure in Sweden, Denmark & Norway
Avintos – UltraPure in Switzerland & Austria

These are all very successful and well managed companies with an active customer base and experience in the fields of bio-production and single use manufacturing. We are confident in the level of expertise and professionalism that each of these companies brings towards increasing adoption of the CleanLine™ Connector and are looking forward to leveraging the relationships and influence of each company to continue to promote this unique technology into the market.

The CleanLine™ 1.5” Single Use Connector is designed for high volume sterile fluid transfers and can be used to provide operational efficiency in many areas of upstream and downstream bioprocessing. As single use bioprocessing has scaled up to 2,000 liters or more there is an increased need to also increase the size of the tubing assemblies needed to move fluid from one process step to another. The CleanLine™ Connector can provide fluid flow rates of up to 290 liters/minute, hold pressures of up to 80 psi or a vacuum of up to 26” Hg. It is a very robust and reliable product that can also work with hybrid stainless steel / single use systems that use standard 1.5” sanitary ports.

For more information on the CleanLine™ Connector, Refine Technology or any of our partner distribution companies from the Indutrade Group please visit our website at


Chris Bartlett
Business Development Director
Refine Technology
+1.973.952.0002 ext 302

Semitorr Group to Distribute Refine Technology CleanLine Connector on West Coast

Refine Technology Logo

CleanLine Single Use Connector LogoPine Brook, NJ – Refine Technology announces distribution arrangements with Semitorr Group for the West Coast and Texas.  Semitorr Group are leaders in high purity gas and liquid transfer for the food, beverage and life sciences markets and carry a very complementary range of products within the single use bioprocessing industry including valves, pumps, manifolds and bags.  With several regional distribution centers, customers can feel secure in fast delivery times and excellent support and service. They have existing relationships with many of the top biopharmaceutical manufacturers on the west coast and Refine Technology feels very confident in Semitorr’s ability to effectively introduce the benefits of more rapid sterile fluid transfer rates with low shear to the West Coast bioprocess market.

Are you maximizing single use efficiency?

single use efficiency

Single Use connectorCan you get the benefit of single use technology with the reliability typically associated with stainless steel?

There are a variety of ways to define efficiency when it comes to bioprocessing. Single use bioreactor bags (SUB’s) provide efficiency in that they do not have to be cleaned and re-sterilized between manufacturing runs whereas hybrid stainless steel systems can provide an efficiency of scale. You can manufacture in much larger volumes using stainless steel.  Whatever you are using, there’s a good chance the decision was made in consideration of gaining some operational efficiency.

Many articles have been written about the strengths and weaknesses and the benefits and limitations of using stainless steel, single use or hybrid systems for bioprocessing. Stainless steel technologies have been around for a long time while single use technologies are relatively newer and continue to adapt and evolve. Improvements in capability and scale occur on a regular basis. Whether it be new bioreactor bags, new valves or customized tubing solutions; manufacturers and system integrators work hard to develop unique solutions for their bioprocess customers. While there are some “off the shelf” solutions available, the flexibility of designing more customized systems is one of the strengths of using single use products. They can be designed and built to your specifications using products and materials that you specify regardless of brand or vendor and without an industry defined blueprint for building a bioreactor or component of a bioreactor system.  However, a big challenge to this custom, single use model that has developed is a lack of material and component standardization.  Products and components do not always fit together in simple and effective ways. This can lead to compromises that can adversely affect the efficiency that single use technologies are attempting to create.

One area that has largely been overlooked when it comes to single use bioprocessing efficiency is the rate of fluid transfer from one stage of the process chain to another. Single use sterile fluid transfer is often limited to the use of ¾” to 1” hoses. Why is this? It is largely because there has not yet been a reliable way to connect hoses larger than 1” in diameter. Reliability comes into question at larger sizes, higher pressures and higher flow rates. Concerns about single use connector leakage and product failure occur as fluid volume transfers increase and there have not historically been any options at this size.

  • Many large single use bioreactor bags limit their operational efficiency due to smaller than necessary bag ports and transfer tubing.
  • Many stainless steel systems come with a 1.5″ TC port that has to be scaled down due to limitations in single use connector sizing.


This does not have to be the case. As single use bioreactor bags scale up in size to 1,000, 2,000 or even 3,500 liters it is necessary for tubing and connectors to scale up in size accordingly. Otherwise some of the anticipated efficiencies provided by single use are lost. Options are now available to bridge this bottleneck and to help allow for sterile fluid flow rates of up to 290 liters per minute that are more appropriate for larger scale systems. To learn about Refine Technology’s new CleanLine™ 1.5″ Single Use Connector and to improve your process efficiency, visit us on LinkedIn or check out our new website.  Let us help you maximize your single use bioprocessing efficiency.


Chris Bartlett

Business Development Director

Refine Technology