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New Refine Technology YouTube Channel

Pine Brook, NJ – August 13, 2020

As the world continues to sell and market products differently and as a company seeking to bring awareness to two new technologies, Refine Technology has developed a new YouTube Channel to promote and provide technical details on the CORe Mini BioReactor System and CleanLine 1.5″ Single Use Connector.CleanLine with TC End

Click the link below to learn more about how we can provide bioprocess efficiencies in fluid flow management and in cell culture optimization.

Refine Technology YouTube Channel

Please subscribe, comment and come back to see us.  We plan to continue to develop new content and hope that we can get out to do more product demos soon.

CORe Mini BioReactor

CleanLine™ Connector Product Improvements

Pine Brook, NJ, July 6, 2020 — With a mind towards continued product improvement, Refine Technology, LLC has made significant enhancements to the CleanLine™ 1.5” Single Use Connector.  Designed for high volume sterile fluid transfers, the CleanLine™ connector creates a larger flow path than existing single use connectors on the market enabling flow rates of up to Rivets Connected290 liters/minute.  This durable technology can hold up to 80 psi and a vacuum hold of 26” Hg.  It is an excellent fit for large single use bags and making hybrid single use connections to stainless steel skids that utilize standard 1.5” ports.

Thanks to the voice of our customers and distribution partners, we have improved the mechanism that locks the connector in place to provide a solid seal.  Our new Twist Lock Rivets are very simple to use with audible signals to ensure confidence in a tight seal between the O-rings. Simply press the rivets through the connector and twist over the edge for a secure connection.Twist Lock Rivets

Please take a look at our video to see how easy the CleanLine Connector can be connected.  For more information, please visit our website at or reach out to us directly.


Chris Bartlett
Head of Sales & Marketing
Office) 973.952.0002 ext 302
Mobile) 518.727.6747

Introducing the new CleanLine™ 1.5” TC Connector

June 25, 2019

Based on industry feedback, Refine Technology has introduced a Tri Clamp version of the CleanLine™ 1.5” Single

CleanLine TC Connector

CleanLine TC Connector with polysulfone rivets attached.

Use Connector.  This new version of the product adds significant versatility to applications where the CleanLine™ products can manage higher sterile fluid transfer rates. The TC end is a natural fit for many single use / stainless steel hybrid facilities that incorporate 1.5” stainless steel tubing and TC fittings without the need to reduce the fluid flow path in order to maintain flow rates of up to 290 liters per minute.  The CleanLine 1.5” TC Connector is also an excellent option for use with larger pumps, valves and manifolds which may have 1.5” TC ends.

In conjunction with the new connector option, the stainless steel bolt has been replaced by a long polysulfone rivet for a true single use product.  The rivet easily snaps onto the connector to create a secure connection capable of withstanding up to 80 psi.

We invite you to take a look at our updated website and product video which shows the some of the various application areas for the CleanLine™ Connector.  In an effort to continue using the Voice of Customer to improve our product offerings, we also invite you to take a brief survey to tell us what you think.  Thank you to everyone that assisted us in making these product updates.  We hope you will find them beneficial towards improving your overall process efficiency.


Refine Technology in Puerto Rico

March 16, 2018 – Pine Brook, NJ

Refine Technology is very pleased to present LA Industrial Supply as its new distribution partner in Puerto Rico. LA Industrial Supply is a leading provider of high quality hygienic seals, sanitary gaskets, hose assemblies, valve, pump and filler machinery components in a wide range of high purity elastomer materials.

CleanLine Connector

CleanLine 1.5″ Single Use Connector

LA Industrial Supply’s contacts and expertise in the field of biopharmaceutical manufacturing in Puerto Rico make them an excellent partner to promote Refine Technology’s CleanLine™ 1.5″ Single Use Connector in an area known for biopharmaceutical manufacturing. We are looking forward to expanding awareness and use of the CleanLine Connector to improve sterile flouid flow rates in Puerto Rico.

For more information on LA Industrial Supply and their product offerings, please visit their website at: LA Industrial Supply

For more information on Refine Technology and the CleanLine™ 1.5″ Single Use Connector, please visit us at: Refine Technology


Chris Bartlett

Business Development Director

Refine Technology

+1-973-962-0002 ext 302


New Distribution Partners for Refine Technology in Europe

January 22, 2018

Refine Technology is pleased to announce new partnerships in Europe for the promotion and sale of the CleanLine™ 1.5” Single Use Connector. The company has appointed several of the Indutrade group of companies as distribution partners. Indutrade is an international industrial group that sells high-tech products and solutions helping customers to improve their own products as well as streamline their own production processes. The continued expansion of sales channels in Europe represents a strong indication of the adoption potential for Refine Technology’s unique new connector in various single use bioprocessing applications.

Refine Technology has partnered with the following companies and regions in Europe:

CleanLine Connector

ESI – UltraPure in Ireland & the UK
ESI – Benelux in The Netherlands, Belgium & Luxembourg
Colly – Flowtech/UltraPure in Sweden, Denmark & Norway
Avintos – UltraPure in Switzerland & Austria

These are all very successful and well managed companies with an active customer base and experience in the fields of bio-production and single use manufacturing. We are confident in the level of expertise and professionalism that each of these companies brings towards increasing adoption of the CleanLine™ Connector and are looking forward to leveraging the relationships and influence of each company to continue to promote this unique technology into the market.

The CleanLine™ 1.5” Single Use Connector is designed for high volume sterile fluid transfers and can be used to provide operational efficiency in many areas of upstream and downstream bioprocessing. As single use bioprocessing has scaled up to 2,000 liters or more there is an increased need to also increase the size of the tubing assemblies needed to move fluid from one process step to another. The CleanLine™ Connector can provide fluid flow rates of up to 290 liters/minute, hold pressures of up to 80 psi or a vacuum of up to 26” Hg. It is a very robust and reliable product that can also work with hybrid stainless steel / single use systems that use standard 1.5” sanitary ports.

For more information on the CleanLine™ Connector, Refine Technology or any of our partner distribution companies from the Indutrade Group please visit our website at


Chris Bartlett
Business Development Director
Refine Technology
+1.973.952.0002 ext 302

Semitorr Group to Distribute Refine Technology CleanLine Connector on West Coast

Refine Technology Logo

CleanLine Single Use Connector LogoPine Brook, NJ – Refine Technology announces distribution arrangements with Semitorr Group for the West Coast and Texas.  Semitorr Group are leaders in high purity gas and liquid transfer for the food, beverage and life sciences markets and carry a very complementary range of products within the single use bioprocessing industry including valves, pumps, manifolds and bags.  With several regional distribution centers, customers can feel secure in fast delivery times and excellent support and service. They have existing relationships with many of the top biopharmaceutical manufacturers on the west coast and Refine Technology feels very confident in Semitorr’s ability to effectively introduce the benefits of more rapid sterile fluid transfer rates with low shear to the West Coast bioprocess market.

Refine Technology, LLC Establishes East Coast Distribution for new 1.5” Single Use Connector

Refine Technology, LLC Establishes East Coast Distribution for new 1.5” Single Use Connector

Company expects to gain traction for single use bioprocessing applications requiring rapid sterile fluid transfer.

CleanLine Connector Assembly

Assembled CleanLine 1.5″ Single -Use Connector

Pine Brook, NJ  – July 11, 2017.  Today, Refine Technology, most known for developing the award winning ATF™ System for cell perfusion, announced distribution arrangements with three companies to help promote and sell its new CleanLine™ 1.5” Single Use Connector on the east coast.  Refine Technology has partnered with Triangle Process Equipment in Wilson, NC, Accuflow Systems in Frederick, MD and Casella Process Systems in Barrington, NH to help develop the market for improved high volume, low shear sterile fluid flow rates in single use bioprocessing.

“We are very excited to be working with each of these companies,” said Chris Bartlett, Refine Technology’s Business Development Director. “Each company has unique strengths in the bioprocess and single use bioprocessing market as well as existing relationships with each other. Information and resources are shared along the east coast which is a huge benefit to end users looking for a comprehensive and efficient supply chain.”

With flow rates of up to 290 liters/minute, the CleanLine™ 1.5” Single Use Connector was developed to address sterile fluid flow inefficiencies with 2,000 liter or larger single use bags (SUB’s) that are constrained by smaller 1” sterile fluid transfer lines between process steps.  There are many other application areas for this new connector, which was launched in January 2017, including media preparation and transfer, upstream to downstream transfer, sterile waste removal from the process stream, connecting hybrid stainless steel / single use bioreactor systems and any other areas where rapid sterile fluid flow rates with low shear are important.

CleanLine Connector

CleanLine 1.5″ Single Use Connector

According to Erik Mueller, General Manager of Accuflow Systems, “The Cleanline 1.5” Single Use Connector will enable customers to efficiently transfer large volumes of sterile liquid media and shorten the emptying of large bioprocess bags from what used to take hours to minutes, improving operational efficiencies. The sales teams at Accuflow, Triangle and Casella will be able to offer this unique product across the entire east coast and support Refine by stocking the product at all of our warehouses.”

Refine Technology looks to continue expansion of its distribution network across the US and internationally, but views the east coast as a strong cornerstone to help build awareness to this new market for high volume, low shear sterile fluid transfers.


About Refine Technology, LLC, Pine Brook, NJ:  Refine Technology is based in Pine Brook, NJ and was founded in 1999 with a vision to develop and bring to market products in the field of animal cell culture.  Following the successful sale of its award winning ATF system for cell perfusion product, Refine Technology has been developing innovative technologies for the bioprocess and cell culture market that address unmet needs and inefficiencies. Refine Technology, LLC currently has several products in its R&D pipeline that are expected to be released later in 2017.  Further information may be found at:


About Triangle Process Systems, Wilson, NC: Founded by a veteran of the sanitary processing equipment industry, Triangle Process Equipment has dedicated the past 15 years to becoming the industry’s go-to resource. Immersed in the processing equipment industry, our sales representatives have a thorough understanding of the nuances of the pharmaceutical processing, cosmetics manufacturing, food processing and beverage manufacturing markets. By operating with a sales and service approach driven by problem-solving, Triangle Process Equipment delivers specialized solutions to the unique needs of disposable processing equipment customers. Further information may be found at:


About Accuflow Systems; Frederick, MD:  Since 2001, Accuflow Systems has been focused on providing its customers with “Quality products through Quality processes by Quality people.” Over the years Accuflow’s expertise, supplier network and product selection have grown immensely, but its service has stayed responsive, providing its customers with one-on-one attention.  Increasingly, Accuflow’s biotech, pharmaceutical and food manufacturing customers face the challenge of meeting stringent quality demands while keeping costs under control. Accuflow Systems understands these demands and has implemented a Quality Management System to confidently deliver you superior products at competitive prices. Further information may be found at:


About Casella Process Systems, Barrington, NH:  Casella Process Solutions (formerly Casella Sales and Marketing) has been a leading supplier to pharmaceutical and bio-tech manufacturing companies in the Northeast for over 20 years.  Casella specializes in providing technically sophisticated components and equipment for single-use/disposable and traditional stainless steel process applications. Casella’s longstanding relationships with bio-pharm manufacturers and OEMs have given it a depth of understanding of high purity and sterile manufacturing environments. Casella’s success has been built entirely on the quality of its service and the quality of the products it has selected to represent. Further information may be found at:


Media Contact:
Chris Bartlett
Refine Technology, LLC
973-952-0002 ext 302


Are you maximizing single use efficiency?

single use efficiency

Single Use connectorCan you get the benefit of single use technology with the reliability typically associated with stainless steel?

There are a variety of ways to define efficiency when it comes to bioprocessing. Single use bioreactor bags (SUB’s) provide efficiency in that they do not have to be cleaned and re-sterilized between manufacturing runs whereas hybrid stainless steel systems can provide an efficiency of scale. You can manufacture in much larger volumes using stainless steel.  Whatever you are using, there’s a good chance the decision was made in consideration of gaining some operational efficiency.

Many articles have been written about the strengths and weaknesses and the benefits and limitations of using stainless steel, single use or hybrid systems for bioprocessing. Stainless steel technologies have been around for a long time while single use technologies are relatively newer and continue to adapt and evolve. Improvements in capability and scale occur on a regular basis. Whether it be new bioreactor bags, new valves or customized tubing solutions; manufacturers and system integrators work hard to develop unique solutions for their bioprocess customers. While there are some “off the shelf” solutions available, the flexibility of designing more customized systems is one of the strengths of using single use products. They can be designed and built to your specifications using products and materials that you specify regardless of brand or vendor and without an industry defined blueprint for building a bioreactor or component of a bioreactor system.  However, a big challenge to this custom, single use model that has developed is a lack of material and component standardization.  Products and components do not always fit together in simple and effective ways. This can lead to compromises that can adversely affect the efficiency that single use technologies are attempting to create.

One area that has largely been overlooked when it comes to single use bioprocessing efficiency is the rate of fluid transfer from one stage of the process chain to another. Single use sterile fluid transfer is often limited to the use of ¾” to 1” hoses. Why is this? It is largely because there has not yet been a reliable way to connect hoses larger than 1” in diameter. Reliability comes into question at larger sizes, higher pressures and higher flow rates. Concerns about single use connector leakage and product failure occur as fluid volume transfers increase and there have not historically been any options at this size.

  • Many large single use bioreactor bags limit their operational efficiency due to smaller than necessary bag ports and transfer tubing.
  • Many stainless steel systems come with a 1.5″ TC port that has to be scaled down due to limitations in single use connector sizing.


This does not have to be the case. As single use bioreactor bags scale up in size to 1,000, 2,000 or even 3,500 liters it is necessary for tubing and connectors to scale up in size accordingly. Otherwise some of the anticipated efficiencies provided by single use are lost. Options are now available to bridge this bottleneck and to help allow for sterile fluid flow rates of up to 290 liters per minute that are more appropriate for larger scale systems. To learn about Refine Technology’s new CleanLine™ 1.5″ Single Use Connector and to improve your process efficiency, visit us on LinkedIn or check out our new website.  Let us help you maximize your single use bioprocessing efficiency.


Chris Bartlett

Business Development Director

Refine Technology