Refine Technology News Blog

Press Release – BioProcess International 2021

Sep 29, 2021

Refine Technology to showcase new CORe™ Mini BioReactor System and CleanLine™ 1.5” Single Use Connector at Virtual BioProcess International Sept 28-30th, 2021. New product offers a cost effective and bench space saving option for many cell culture applications Pine Brook, NJ  – September 28, 2021.  Refine Technology, LLC, most known for developing the award winning ATF™ System for cell culture perfusion, will be promoting its new CORe™ Mini BioReactor System and the CleanLine™ 1.5” Single Use Connector at the BioProcess International Virtual Conference 2021 .  The CORe™ Mini Bioreactor System is a compact device, has all of the features and performance of larger bioreactors,  without compromising on bench space or budget. Either suspension or adherent cells may be cultured  with the CORe™ System,  with applications in the fields of R&D, Process Development, personalized medicine, and stem cell culture applications.  The compact size and single use, “plug and play”, nature of the bioreactor provides an efficient process not seen in other cell culture systems. With global cell culture experts in attendance, BPI is an ideal setting for us to promote this new technology. The CORe™ Mini BioReactor System is designed for use with pre-sterilized, Single-Use culture vessels, (Vol. 30-100ml). The disposable culture vessel is provided with non-contact pH, Dissolved Oxygen, Temperature and Level sensors. The system accommodates up to eight peristaltic pumps, offers four gas control as well as a variety of vessel configurations for making additions, subtractions, sampling, perfusion and other adaptations customized to your needs.  The miniaturized nature of the system greatly reduces bench space requirements; arranged and sterile nature of the system greatly reduces set-up time and increases its reliability; furthermore, the small working culture volume significantly reduces the requirement for media and other costly reagents. The CleanLine™ 1.5” Single Use Connector is a genderless aseptic connector used for high volume sterile fluid transfer designed to enhance process efficiency. In many fluid transfer cases, a limiting factor is the time it takes to move fluid from one area of the process to another. Whether in a single use system or a hybrid stainless steel to single use application where larger connection ports are more common, rapid fluid transfer through larger hose can provide a tremendous time savings for these critical processes. Refine Technology’s CleanLine™ 1.5″ Connector and custom hose assemblies provide simpler sterile set-up and operational efficiency with higher flow rates than traditionally smaller single use connections. About Refine Technology, LLC; Pine Brook, NJ:  Refine Technology is based in Pine Brook, NJ and was founded in 1999 with a vision to develop and bring to market products in the field of animal cell culture.  Following the successful sale of its award winning ATF™ system for cell perfusion product, Refine Technology has been developing innovative technologies for the bioprocess and cell culture market that address unmet needs and inefficiencies.   Further information may be found at:

New Refine Technology YouTube Channel

Aug 13, 2020

Pine Brook, NJ – August 13, 2020 As the world continues to sell and market products differently and as a company seeking to bring awareness to two new technologies, Refine Technology has developed a new YouTube Channel to promote and provide technical details on the CORe Mini BioReactor System and CleanLine 1.5″ Single Use Connector. Click the link below to learn more about how we can provide bioprocess efficiencies in fluid flow management and in cell culture optimization. Refine Technology YouTube Channel Please subscribe, comment and come back to see us.  We plan to continue to develop new content and hope that we can get out to do more product demos soon.

CleanLine™ Connector Product Improvements

Jul 06, 2020

Pine Brook, NJ, July 6, 2020 — With a mind towards continued product improvement, Refine Technology, LLC has made significant enhancements to the CleanLine™ 1.5” Single Use Connector.  Designed for high volume sterile fluid transfers, the CleanLine™ connector creates a larger flow path than existing single use connectors on the market enabling flow rates of up to 290 liters/minute.  This durable technology can hold up to 80 psi and a vacuum hold of 26” Hg.  It is an excellent fit for large single use bags and making hybrid single use connections to stainless steel skids that utilize standard 1.5” ports. Thanks to the voice of our customers and distribution partners, we have improved the mechanism that locks the connector in place to provide a solid seal.  Our new Twist Lock Rivets are very simple to use with audible signals to ensure confidence in a tight seal between the O-rings. Simply press the rivets through the connector and twist over the edge for a secure connection. Please take a look at our video to see how easy the CleanLine Connector can be connected.  For more information, please visit our website at or reach out to us directly.   Chris Bartlett Head of Sales & Marketing Office) 973.952.0002 ext 302 Mobile) 518.727.6747

Introducing the new CleanLine™ 1.5” TC Connector

Jun 25, 2019

June 25, 2019 Based on industry feedback, Refine Technology has introduced a Tri Clamp version of the CleanLine™ 1.5” Single CleanLine TC Connector with polysulfone rivets attached. Use Connector.  This new version of the product adds significant versatility to applications where the CleanLine™ products can manage higher sterile fluid transfer rates. The TC end is a natural fit for many single use / stainless steel hybrid facilities that incorporate 1.5” stainless steel tubing and TC fittings without the need to reduce the fluid flow path in order to maintain flow rates of up to 290 liters per minute.  The CleanLine 1.5” TC Connector is also an excellent option for use with larger pumps, valves and manifolds which may have 1.5” TC ends. In conjunction with the new connector option, the stainless steel bolt has been replaced by a long polysulfone rivet for a true single use product.  The rivet easily snaps onto the connector to create a secure connection capable of withstanding up to 80 psi. We invite you to take a look at our updated website and product video which shows the some of the various application areas for the CleanLine™ Connector.  In an effort to continue using the Voice of Customer to improve our product offerings, we also invite you to take a brief survey to tell us what you think.  Thank you to everyone that assisted us in making these product updates.  We hope you will find them beneficial towards improving your overall process efficiency.  

Refine Technology in Puerto Rico

Mar 16, 2018

March 16, 2018 – Pine Brook, NJ Refine Technology is very pleased to present LA Industrial Supply as its new distribution partner in Puerto Rico. LA Industrial Supply is a leading provider of high quality hygienic seals, sanitary gaskets, hose assemblies, valve, pump and filler machinery components in a wide range of high purity elastomer materials. CleanLine 1.5″ Single Use Connector LA Industrial Supply’s contacts and expertise in the field of biopharmaceutical manufacturing in Puerto Rico make them an excellent partner to promote Refine Technology’s CleanLine™ 1.5″ Single Use Connector in an area known for biopharmaceutical manufacturing. We are looking forward to expanding awareness and use of the CleanLine Connector to improve sterile flouid flow rates in Puerto Rico. For more information on LA Industrial Supply and their product offerings, please visit their website at: LA Industrial Supply For more information on Refine Technology and the CleanLine™ 1.5″ Single Use Connector, please visit us at: Refine Technology   Chris Bartlett Business Development Director Refine Technology +1-973-962-0002 ext 302  

New Distribution Partners for Refine Technology in Europe

Jan 22, 2018

January 22, 2018 Refine Technology is pleased to announce new partnerships in Europe for the promotion and sale of the CleanLine™ 1.5” Single Use Connector. The company has appointed several of the Indutrade group of companies as distribution partners. Indutrade is an international industrial group that sells high-tech products and solutions helping customers to improve their own products as well as streamline their own production processes. The continued expansion of sales channels in Europe represents a strong indication of the adoption potential for Refine Technology’s unique new connector in various single use bioprocessing applications. Refine Technology has partnered with the following companies and regions in Europe: CleanLine Connector ESI – UltraPure in Ireland & the UK ESI – Benelux in The Netherlands, Belgium & Luxembourg Colly – Flowtech/UltraPure in Sweden, Denmark & Norway Avintos – UltraPure in Switzerland & Austria These are all very successful and well managed companies with an active customer base and experience in the fields of bio-production and single use manufacturing. We are confident in the level of expertise and professionalism that each of these companies brings towards increasing adoption of the CleanLine™ Connector and are looking forward to leveraging the relationships and influence of each company to continue to promote this unique technology into the market. The CleanLine™ 1.5” Single Use Connector is designed for high volume sterile fluid transfers and can be used to provide operational efficiency in many areas of upstream and downstream bioprocessing. As single use bioprocessing has scaled up to 2,000 liters or more there is an increased need to also increase the size of the tubing assemblies needed to move fluid from one process step to another. The CleanLine™ Connector can provide fluid flow rates of up to 290 liters/minute, hold pressures of up to 80 psi or a vacuum of up to 26” Hg. It is a very robust and reliable product that can also work with hybrid stainless steel / single use systems that use standard 1.5” sanitary ports. For more information on the CleanLine™ Connector, Refine Technology or any of our partner distribution companies from the Indutrade Group please visit our website at   Chris Bartlett Business Development Director Refine Technology +1.973.952.0002 ext 302 +1.518.727.6747

Come see us!

Dec 01, 2017

American Society of Cell Biology Meeting Come see us at the American Society of Cell Biology Meeting December 2-6 in Philadelphia, PA.

Announcing BioZed Engineering as Refine Technology’s Newest Distributor in India

Oct 23, 2017

Refine Technology is very pleased to announce BioZed Engineering as its Distribution Partner for India, Bangladesh, Nepal and Sri Lanka. BioZed Engineering is based in Mumbai with branch offices in New Delhi and Bangalore providing excellent coverage and support across all of India. BioZed’s strengths in single use technologies and bioreactors make them an ideal partner for Refine Technology because they are able to manage sales and support of the CleanLine™ 1.5″ Single Use Connector and the new CORe™ Mini Bioreactor. India is an important market for Refine Technology to get into because of its growing biopharmaceutical manufacturing and increased adoption of single use technologies as well as the strong research institutions looking for cost effective mini bioreactor options. Refine Technology is looking forward to continuing to build a strong presence in India and working with BioZed Engineering as a new partner. For more information about BioZed Engineering, please visit BioZed Engineering or send them an e-mail at: For more information on Refine Technology, please visit us at: Refine Technology or call / e-mail us at: +1 973.952.0002 ext 302 /

Product Launch for new CORe™ Mini Bioreactor

Sep 21, 2017

Thursday September 21, 2017 Refine Technology is pleased to announce the release of its new CORe™ Mini Bioreactor. The CORe™ Culture Optimization Compact, stand-alone Culture Optimization Reactor system. Reactor is a stand-alone and cost effective bioreactor system that is compact and flexible in design. The convenient on-board controls and touch screen display eliminates the need for a bulky external controller thus saving valuable bench space and facilitating ease of portability. The unit can be operated on a bench, in a laminar flow hood or even on a desk. Data is easily exported via an ethernet connection into common analysis programs. The addition of multiplexing capabilities will be forthcoming. The pre-sterilized single use vessel offers a working capacity of 35-100ml which allows significant savings in media costs without compromising performance. Sensors for temperature, pH and DO are all in wall, minimizing contamination risks and interference from the inserts. The only product contact surface is the impeller and shaft which also contains the sparger allowing for gas additions including O2, CO2, N2 and air. Various impeller and sparger designs may be custom ordered to fit user requirements. The CORe™ Mini Bioreactor includes four pumps with an option of up to eight pumps for flexible media handling. Sampling can be performed from both top and bottom ports which facilitate access to and from the vessel. They also provide a convenient connection to a cell concentration device. It can be configured for batch, fed batch or continuous operation. Please join us on September 26-28 at Biotech Week Boston.  Systems will be on display at booth #1124.

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Semitorr Group to Distribute Refine Technology CleanLine Connector on West Coast

Jul 17, 2017

Pine Brook, NJ – Refine Technology announces distribution arrangements with Semitorr Group for the West Coast and Texas.  Semitorr Group are leaders in high purity gas and liquid transfer for the food, beverage and life sciences markets and carry a very complementary range of products within the single use bioprocessing industry including valves, pumps, manifolds and bags.  With several regional distribution centers, customers can feel secure in fast delivery times and excellent support and service. They have existing relationships with many of the top biopharmaceutical manufacturers on the west coast and Refine Technology feels very confident in Semitorr’s ability to effectively introduce the benefits of more rapid sterile fluid transfer rates with low shear to the West Coast bioprocess market.

26 Chapin Road Unit 1107
PO Box 691
Pine Brook, NJ 07058
Tel: 973-952-0002 | Fax: 973-952-0211