DOWNLOADS
Commercial Evidence
Presentations and posters by organizations and companies using the ATF System in their development and manufacturing facilities,
and other conference presentations or posters.
Academic Publications
University and Government research publications, presentations and references relating to the ATF System.
Published Articles of the ATF System
Media and published articles concerning the ATF System.
Applications
Research papers and application documents, conference presentations and media articles.
Refine Media Resources
Refine Technology presentations, graphics and public information for download. These may be used in presentations and by media
companies.
Commercial Evidence
Intensification of a PER.C6®-based recombinant Ad35 manufacturing process to prepare for commercial scale production
Marcel de Vocht, Crucell, December 2008
This presentation shows the rapid progress Crucell is making with their TB vaccine manufacturing process. The ATF System is used in a variety of different ways at Crucell, for example cell banking and a modified perfusion application. They have reported such good gains in productivity that, coupled with disposable bioreactors, they have been able to avoid building a new facility for their manufacturing, and expect to produce the market supply needed with a modest retrofit of their existing facility.
Equipment design and process challenges with running a perfusion process in a disposable stirred-tank: A case study
Nicole E. Richardson, Barbara Chiang,
Centocor R&D, USA 2007
A presentation with process and engineering data explaining bioreactor operation and control. Some scale-up challenges are also discussed.
Large Scale Disposable Bioreactor for Vaccines Manufacturing: Applications to Anchorage Dependent Cell line
Eric Calvosa, Sanofi Pasteur, June 2009
An analysis of the Nucleo single use bioreactor by ATMI used for vaccine production processes based upon microcarriers. Cell amplification and cell banking are presented, and the ATF System (microcarrier version) is used as the filtration device.
Academic Publications
Fed-batch or perfusion for the production of biopharmaceuticals by animal cell cultivation?
Véronique Chotteau, Ph.D.
Bioprocessing Group, Royal Stockholm
Technical University (KTH), SE 2009
KTH has performed an initial series of experiments with the ATF System to test its application in cell culture with a low
performing cell line. Results, simple economic models and a comparison of other available perfusion systems are presented.
Study of a perfusion process of Chinese Hamster Ovary cells by ATF System filtration in bioreactor
Karin Tördahl, Philip Perroud,
Véronique Chotteau, Ph.D.
Bioprocessing Group, Royal Stockholm
Technical University (KTH), SE 2009
A second series of experiments was carried out and they are described here, covering high cell density cultures and the
problems this brings, such as oxygen transfer limitation.
Published Articles on the ATF System
Introduction to the ATF System and it's advantages (in German)
Dr. Christian Hetzel, P&A-Kompendium November 2009
This article describes perfusion and cell retention devices and the ATF System itself in detail.
CMC ICOS Biologics, USA 2009
Jason Carstens, Director Upstream Process Development, Seattle, USA CMC Biopharmaceuticals, DK 2009
Provides an introduction to perfusion as mode of manufacturing for biotherapeutics including the challenges and advantages,
plus this shows an overview of the economics. This presentation was originally shown as a webcast via the Bioprocess
International webinar series
Viral vaccine processes:
Towards intensification and quality
Marcel de Vocht, Crucell, October 2010
Crucell has developed a high cell density vaccine production process with the ATF System. This presentation looks at the downstream process and how it can be intensified while controlling quality. Options for technology transfer out of R&D are also covered.
Scale-up of an Intensified rAd35 Vaccine Production Process in Disposable Bioreactors to Support Global Vaccine
Manufacture
Alfred Luitjens, Crucell
June 9th, 2010
BIOTECHNICA 2010 - Produkthighlights
Interphex Roundtable Series
http://bpiroundtables.com
A review of Biotechnica 2010 with a link to the ATF System shown during the exhibition.
Bringing Innovation to Global Health
Jerald Sadoff, Crucell, September 2010
http://www.tbvaccine2010.org
An overview of the clinical and manufacturing history of Crucell's TB vaccine candidate.
BioProcess RoundTables
Interphex Roundtable Series
http://bpiroundtables.com
Applications
Cell Banking
Read about Cell Banking and Seed Expansion in more detail
Cell Banking / Seed Expansion Application
Which Process Option is Right for Me?
Read about your different process options in more detail
Which Process Option is Right for Me?
Perfusion
Read more on perfusion using the ATF System
Perfusion / Cell Retention Application
ATF-manufacturing Platform
Upstream Unit Operations
Concentrated Perfusion
ATF-manufacturing Platform
Upstream Unit Operations
Vaccines
Gene Therapy
Stem Cells
REFINE SHOWCASE
ADDITIONAL RESOURCE
- Please click on the logo below to visit the BioResearch web pages
EVENTS
- Please join us at the following conferences & exhibitions:
Jun
04
June 04 - June 06, 2012
IBC’s Single Use Applications for BioPharmaceutical Manufacturing
San Francisco
Jun
18
June 18 - June 21, 2012
2012 Bio International Convention
Boston, Massachusetts
Aug
21
August 21 - August 22, 2012
BioProcess International China 2012
Shanghai
Oct
03
October 03 - October 03, 2012
Boston ISPE 2012 Product Show
Foxboro, Massachusetts
REFINE NEWS
- Click on the links below to view the full Refine News article.