CELL CONCENTRATION / RAPID MEDIUM EXCHANGE

Cell viability is critical for these applications where the quality or expression of the product could be affected by slow or damaging processing. The ATF™ System provides a significant benefit over other equipment such as TFF, depth filtration or centrifuges due to its low shear and ability to filter material fast.

Previously an operator would be happy with a 3-4 hour step for concentrating 20m cells to 200m at 50L for example. The ATF System simplifies the development of the manufacturing process by streamlining the operation, achieving results 3-4 times faster, generally reducing the manual handling of cells and so minimizing risks at all times. Normally, both the capital costs and the overall cost of ownership are reduced. For example, a 200L single use bioreactor can be concentrated to 20L in an hour assuming cell densities of 20-50m/ml, while ensuring cell viability does not drop.